Trends in pediatric circumcision in Belgium and the Brussels University Hospital from

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Prevention of cervical cancer

HPV (human papillomavirus) is one of the most common sexually transmitted infections in the United States of America. Persistent infection with high-risk HPV types (mainly HPV type 16 and 18) is a prerequisite to developing cervical squamous carcinoma.21 A large multinational study published in the New England Journal of Medicine in 2002 showed that circumcised males have a lower incidence of HPV detection compared to uncircumcised males (5.5% versus 19.6%). The rate of cervical cancer in women whose partner had more than 6 sexual partners was significantly lower when their partner was circumcised. Thus circumcision can be considered an important cofactor in the natural history of HPV infection, as it may influence the risk of the acquisition and transmission of HPV as well as the risk of cervical cancer.9

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