The Creation Hypothesis says: Physical space-time and its contents were created by beings outside physical space-time.
This is a familiar hypothesis. A version of it is believed by many people in our society, and perhaps by the majority of the people in the world. If one believes that God created the world, and if one believes that God is outside physical space-time, then one believes the Creation Hypothesis. One needn't believe in God to believe the Creation Hypothesis, though. Perhaps our world was created by a relatively ordinary being in the "next universe up", using the latest world-making technology in that universe. If so, the Creation Hypothesis is true.
I don't know whether the Creation Hypothesis is true. But I don't know for certain that it is false. The hypothesis is clearly coherent, and I cannot conclusively rule it out.
The Creation Hypothesis is not a skeptical hypothesis. Even if it is true, most of my ordinary beliefs are still true. I still have hands, I am still in Tucson, and so on. Perhaps a few of my beliefs will turn out false: if I am an atheist, for example, or if I believe all reality started with the Big Bang. But most of my everyday beliefs about the external world will remain intact.