The objective of this talk is to give an overview in several areas. The first task is to present some basic models of brain function that support the case for neurofeedback. Secondly, the basic approaches to neurofeedback will be classified, yielding further implications for brain models. Thirdly, the attempt will be made to connect the principal neurofeedback approaches with the standard formulations of psychopathology in terms of classical disorders and of neurophysiological failure modes. Finally, the case will be made for a systems perspective on disorders of disregulation, with neurofeedback and biofeedback constituting a comprehensive self-regulation remedy.