Mycoplasmal Infections in Chronic Illnesses: Fibromyalgia and Chronic Fatigue Syndromes, Gulf War Illness, hiv-aids and Rheumatoid Arthritis



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Medical Sentinel 1999;4:172-176.

Medical Sentinel is the official, peer-reviewed journal of the Association of American Physicians and Surgeons (AAPS).

Mycoplasmal Infections in Chronic Illnesses: Fibromyalgia and Chronic Fatigue Syndromes, Gulf War Illness,

HIV-AIDS and Rheumatoid Arthritis
Prof. Garth L. Nicolson, PhD, Marwan Y. Nasralla, PhD, Joerg Haier, MD, PhD,

Robert Erwin, MD, Nancy L. Nicolson, PhD, and Richard Ngwenya, MD


The Institute for Molecular Medicine, 16371 Gothard Street H, Huntington Beach, CA 92647 and

James Mobb Immune Enhancement, Harare, Zimbabwe
ABSTRACT Invasive bacterial infections are associated with several acute and chronic illnesses, including: aerodigestive diseases such as Asthma, Pneumonia, Inflammatory Bowel Disease; rheumatoid diseases, such as Rheumatoid Arthritis (RA); immunosuppression diseases such as HIV-AIDS; Genitourinary Infections and chronic fatigue illnesses such as Chronic Fatigue Syndrome (CFS), Fibromyalgia Syndrome (FMS) and Gulf War Illnesses (GWI). It is now apparent that such infections could be (a) causative, (b) cofactors or (c) opportunistic agents in a variety of chronic illnesses. Using Forensic Polymerase Chain Reaction we have looked for the presence of one class of invasive infection (mycoplasmal infections) inside blood leukocyte samples from patients with CFS (Myalgic Encephalomyelitis ), FMS, RA and GWI. There was a significant difference between symptomatic CFS, FMS, GWI and RA patients with positive mycoplasmal infections of any species (45-63%) and healthy positive controls (~9%) (P<0.001). This difference was even greater when specific species (M. fermentans, M. hominis, M. penetrans, M. pneumoniae) were detected. Except for GWI, most patients had multiple mycoplasmal infections (more than one species of mycoplasma). Patients with different diagnoses but overlapping signs and symptoms often have mycoplasmal infections, and such mycoplasma-positive patients generally respond to multiple cycles of particular antibiotics (doxycycline, minocycline, ciprofloxacin, azithromycin and clarithromycin). Multiple cycles of these antibiotics plus nutritional support appear to be necessary for successful treatment. In addition, immune enhancement and other supplements appear to help these patients regain their health. Other chronic infections may also be involved to various degrees with or without mycoplasmal infections in causing patient morbidity in various chronic illnesses.


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