Mary E. Lidstrom, Ph. D. Curriculum vitae (formerly Mary L. O'Connor) Education

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Mary E. Lidstrom, Ph.D. CURRICULUM VITAE

(formerly Mary L. O'Connor)



B.S., Oregon State University, Corvallis, Oregon, with honors (Microbiology)


M.S., University of Wisconsin, Madison, Wisconsin (Bacteriology) "Isoenzymes from a Facultative Methylotroph"


Ph.D., University of Wisconsin, Madison, Wisconsin (Bacteriology) "Regulation of C-1 Metabolism in Methylobacterium organophilum"

Postgraduate Training


Leverhulme Visiting Fellow, Professor J. R. Quayle,


Department of Microbiology, Sheffield, England. Mutant and enzymological studies of a variety of methylotrophic bacteria and yeasts.

Faculty Positions Held

Sept. 1978

Assistant Professor, Department of Microbiology and Immunology, University of Washington, Seattle, Washington.

Dec. 1982

Adjunct Assistant Professor, Department of Oceanography, University of Washington, Seattle, Washington.

Oct. 1984

Associate Professor, Department of Microbiology and Immunology, University of Washington, Seattle, Washington.

July 1985

Associate Scientist, Center for Great Lakes Studies, and Associate Professor, Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.

May 1987

Associate Professor, Environmental Engineering Science, California Institute of Technology, Pasadena, California.

Sept 1991

Professor, Environmental Engineering Science, California Institute of Technology, Pasadena, California.

June 1996

Jungers Professor of Chemical Engineering and Professor of Microbiology, University of Washington, Seattle

Sept. 1997

Associate Dean for New Initiatives in Engineering, University of Washington, Seattle

Dec. 2000-2006

Adjunct Professor of Bioengineering, University of Washington, Seattle

Aug. 2001

Director, Microscale Life Sciences Center, University of Washington, Seattle (an NIH Center of Excellence in Genome Science)

Aug. 2002

Howard Hughes Medical Institute Professor



Kappa Kappa Gamma Graduate Fellowship


National Science Foundation Graduate Fellowship


American Association of University Women Graduate Fellowship


Leverhulme Visiting Fellowship


Prather Award for Young Women in Science


Caltech Award for Excellence


NSF Faculty Award for Women


Fellow of the American Academy of Microbiology


Caltech Associated Students Distinguished Teaching Award


American Society for Microbiology Divisional Lecturer


Jungers Endowed Professorship in Engineering


Board of Governors, American Academy of Microbiology


Howard Hughes Medical Institute Professor


AAAS Fellow


ASM Graduate Microbiology Teaching and Mentoring Award


American Society for Microbiology Lecturer


American Society for Microbiology Proctor & Gamble Award for Applied and Environmental Microbiology


National Academy of Sciences, Elected Member


  • Society for General Microbiology

  • American Society for Microbiology

  • AAAS

  • National Academy of Sciences

Scientific Activities

Editorial and Review Boards:


American Editor, Antonie van Leeuwenhoek Journal of Microbiology


Editorial Board, Applied and Environmental Biology


Editorial Board, Journal of Bacteriology


Editorial Board, Annual Reviews of Microbiology


Editorial Board, FEMS Microbiological Reviews


Editorial Board, Microbiology (UK)


NIH Study Section, NIGMS Microbial Physiology and Genetics, subcommittee 1


EPA Environmental Biology Review Panel


Review Panel, California Hazardous Substances Program, Palo Alto, CA


American Society for Microbiology Awards Committee


Moore Foundation Marine Microbiology Initiative Review Board

Advisory Boards


PNNL External Advisory Committee


Beckman Institute External Advisory Committee, Caltech


Center for Process Analytical Chemistry Advisory Board, UW


Center for Bioinorganic Chemistry Advisory Board, Princeton


Human Interface Technology Laboratory Policy Board, UW


DOE Energy Biosciences Council


Environmental Sciences Division of the Oak Ridge National Laboratory


National Academies, National Research Council Committee, “A New Biology for the 21st Century



US/USSR Microbiology Working Group/Tour of Soviet Universities


AAUW Careers Workshop, Seattle, Washington

1983, 1984

University of Washington Extension Workshop on Microbiology


Gas Research Institute Workshop on Biological Activation of Methane


NASA Workshop on Atmospheric Methane Research Opportunities


NSF Workshop on Microbial Ecology Directions


ASM Workshop on Environmental Gene Probes


DOE Working Group, Environmental Molecular Biology


DOE Workshop on Applications of Molecular Biology to Global Change


ONR Bioremediation Workshop, 1992


AAM Workshop on Bioremediation, 1992


AAM Workshop on Site Demonstrations for Bioremediation, 1993


NSF Panel Workshop on Future Directions for Microbiology Research


AAM Workshop on Microbial Diversity, 1996


NATO Workshop on Microbial Electron Transport Chains, 1997


Workshop on IE Clusters, 1997


NSF Workshop on Future Directions in Physiology (Organizing Committee)


NSF Workshop on Metabolic Engineering


NAE Workshop on Biology in Engineering Education


NHGRI Workshop on Recruitment of Underrepresented Minorities


British Petroleum Futures Forum


NIGMS Visions of the Future Workshop (group leader)


NHGRI Future of Genomics Workshop


BECON Team Science Workshop (group leader)


American Academy of Microbiology Futures Colloquium


NIH Symposium on Team Science (Group 4 moderator)


Office of Science Technology Policy Regional Forum on Team Research


NAS National Academies Keck Futures Initiative


NIH Workshop on the Future of Microbial Biology Research


World Conference of Women Leaders (workshop leader)


NIH Workshop on the Human Microbiome


DOE-BER GTL Annual Contractor-Grantee Workshop


Systems Microbiology and Extremophile Research Facility Workshop


National Science Foundation IGERT Workshop


ARPA-E Biological Technologies for Methane-to-Liquid Fuels Workshop


ARPA-E Energy Innovation Summit

Special Lectures


ACS Radio Program, Dimensions in Science, "Methane and the Greenhouse Effect"


ASM Foundation Lecturer


Caltech Watson Public Lecture

1990, 1995

USC Engineering School Distinguished Lecturer Series


Caltech SURF Lecture


UW Science Forum Lecture


UW Public Science Lecture


Howard Hughes Medical Institute 50th Anniversary Symposium, November


NSF Biology Distinguished Lecture, “Mining the global gene pool: the discovery of novel groups of microorganisms in the environment”



Co-Director, Caltech DARPA-URI Hazardous Waste Center, 1992-96


Program Director, Caltech NIH Biotechnology Training Grant, 1992-96


Director, Microscale Life Sciences Center, (an NIH Center of Excellence in Genome Science)


Director, UW Genome Outreach to Minorities Program

Administrative Positions


Vice-Chair of the Faculty, Caltech


Associate Dean for New Initiatives in Engineering, UW


Vice Provost for Research, UW



Interim Provost and Executive Vice President, UW

Vice Provost for Research, UW

Current University Committees

President’s Cabinet

Research Advisory Board (Chair)

IT Roadmap Executive Sponsors

President's Advisory Committee on Enterprise Risk Management

ABB Steering Committee

Two years to Two Decades Steering Committee

UW IT Strategic Board

Faculty Council for Research (ex officio)

Hyak Steering Committee (Chair)

Ocean Observatory Initiative Advisory Committee

Fostering Collaboration Imitative (Chair)

Strategic Initiatives Oversight Board
Peer-Reviewed Publications

  1. Trewyn, R. W., K. D. Nakamura, M. L. O'Connor, and L. W. Parks. 1973. An interaction between S-adenosylmethionine and pyridoxal-5'phosphate and its effect on Saccharomyces cerevisiae. Biochem. Biophys. Acta 327:336-344.

  2. O'Connor, M. L. and R. S. Hanson. 1975. Serine trans-hydroxymethylase isoenzymes from a facultative methylotroph. J. Bact. 124:985-996.

  3. O'Connor, M. L., A. Wopat and R. W. Hanson. 1977. Genetic transformation in Methylobacterium organophilum. J. Gen. Micro. 98:265-272.

  4. O'Connor, M. L. and R. S. Hanson. 1977. Regulation of enzymes in Methylobacterium organophilum. J. Gen. Micro.101:327-332.

  5. O'Connor, M. L. and R. S. Hanson. 1978. Linkage relation-ships between mutants in Methylobacterium organophilum impaired in their ability to grow on one-carbon compounds. J. Gen. Micro. 104:105-111.

  6. Bamforth, C. W. and M. L. O'Connor. 1979. The isolation of pleiotropic mutants of Pseudomonas aminovorans deficient in their ability to grow on methylamine and an examination of their enzymic constitution. J. Gen. Micro. 110:143-149.

  7. O'Connor, M. L. and J. R. Quayle. 1979. Mutants in Hansenula polymorpha and Candida boidinii deficient in the ability to grow on methanol. J. Gen. Micro. 113:203-208.

  8. O'Connor, M. L. and J. R. Quayle. 1980. Pentose-phosphate dependent fixation of formaldehyde in methanol-grown Hansenula polymorpha and Candida boidinii. J. Gen. Micro.120:219-226.

  9. McNerney, T. and M. L. O'Connor. 1980. Regulation of Cl enzymes in three facultative methylotrophs. Appl. Env. Micro. 40:370-375.

  10. Lynch, M. J., A. E. Wopat and M. L. O'Connor. 1980. Isolation and characterization of two new facultative methanotrophs. Appl. Env. Micro. 40:400-407.

  11. O'Connor, M. L. 1981. Extension of the model concerning linkage of genes coding for C-1 related functions in Methylobacterium organophilum. Appl. Env. Micro. 41:437-441.

  12. Lidstrom, M. E., J. E. Engebrecht and K. H. Nealson. 1983. Plasmid-mediated manganese oxidation in a marine pseudomonad. FEMS Microbiol. Lett. 19:1-6.

  13. Lidstrom, M. 1983. Methane consumption in Framvaren, an anoxic marine fjord. Limnology and Oceanography 28:1247-1251.

  14. Lidstrom, M. E., A. E. Wopat and G. L. Fulton. 1983. Methylobacterium ethanolicum, a syntrophic association between two methylotrophic bacteria. J. Gen. Microbiol. 129:3139-3148.

  15. Murrell, J. C. and M. E. Lidstrom. 1983. Nitrogen assimilation in Xanthobacter H4-14. Arch. Microbiol. 136:219-221.

  16. Strand, S. and M. E. Lidstrom. 1984. Isolation and characterization of a new marine methylotroph. FEMS Microbiol. Lett. 21:247-251.

  17. Toukdarian, A. E. and M. E. Lidstrom. 1984. DNA hybridization analysis of the nif region of Methylosinus 6. J. Bacteriol. 157:925-930.

  18. Toukdarian, A. E. and M. E. Lidstrom. 1984. Molecular construction and characterization of nif mutants in Methylosinus 6. J. Bacteriol. 157:979-983.

  19. Lidstrom, M. E. and L. Somers. 1984. Seasonal study of methane consumption in Lake Washington. Appl. Environ. Microbiol. 47:1255-1260.

  20. Schellenberg, G. D., A. Sarthy, A. E. Larson, M. P. Backer, J. W. Crabb, M. Lidstrom, B. D. Hall and C. E. Furlong. 1984. Xylose isomerase from Escherichia coli. Characterization of the protein and the structural gene. J. Biol. Chem. 259:6826-6832.

  21. Toukdarian, A. E. and M. E. Lidstrom. 1984. Nitrogen metabolism in Methylosinus 6, a new obligate methanotroph. J. Gen. Microbiol. 130:1827-1837.

  22. Lidstrom, M. E. and A. E. Wopat. 1984. Plasmids in methanotrophic bacteria: isolation, characterization and DNA hybridization analysis. Arch. Microbiol. 140:27-33.

  23. Fulton, G. F., D. N. Nunn and M. E. Lidstrom. 1984. Molecular cloning of a malyl CoA lyase gene (Mcl) from Pseudomonas AM1, a facultative methylotroph. J. Bacteriol. 160:718-723.

  24. Lehmicke, L. and M. E. Lidstrom. 1985. Genetics of autotrophy and hydrogen oxidation in Xanthobacter H4-14, a methanol autotroph. J. Bacteriol.162:1244-1249.

  25. Weaver, C. W. and M. E. Lidstrom. 1985. Methanol dissimilation in Xanthobacter H4-14: activities, induction and comparison to Pseudomonas AM1 and Paracoccus denitrificans. J. Gen. Microbiol. 131:2183-2197.

  26. Nunn, D. and M. E. Lidstrom. 1986. Isolation and complementation analysis of ten methanol oxidation (Mox) mutant classes and the identification of the methanol dehydrogenase structural gene of Methylobacterium AM1. J. Bacteriol. 166:581-590.

  27. Nunn, D. and M. E. Lidstrom. 1986. Phenotypic characterization of ten methanol oxidation (Mox) mutant classes in Methylobacterium AM1. J. Bacteriol. 166:591-597.

  28. Cavanaugh, C. M., P. R. Levering, J. S. Maki, R. Mitchell and M. E. Lidstrom. 1987. Symbiosis of methylotrophic bacteria and deep sea mussels. Nature 325:346-348.

  29. Weaver, C. W. and M. E. Lidstrom. 1987. Genetics of methanol dissimilation in Xanthobacter H4-14, a methanol autotroph. J. Gen. Microbiol. 133:1721-1731.

  30. Sieburth, J. M., P. W. Johnson, M. A. Eberhardt, M. E. Sierocki, M. E. Lidstrom and D. Laux. 1987. The first methane-oxidizing bacterium from the upper mixing layer of the deep ocean: Methylomonas pelagica sp. nov. Curr. Microbiol. 14:285-293.

  31. Little, C. D., A. V. Palumbo, S. E. Herbes, M. E. Lidstrom, R. L. Tyndall and P. J. Gilmer. 1988. Trichlorethylene biodegradation by a methane-oxidizing bacterium. Appl. Environ. Microbiol. 54:951-956.

  32. Stephens, R. L., M. G. Haygood and M. E. Lidstrom. 1988. Identification of putative methanol dehydrogenase (moxF) structural genes in methylotrophs and cloning of moxF genes from Methylococcus capsulatus Bath and Methylomonas albus BG8. J. Bacteriol. 170:2063-2069.

  33. Anderson, D. A. and M. E. Lidstrom. 1988. The "moxFG" region encodes four polypeptides in the methanol-oxidizing bacterium, Methylobacterium sp. strain AM1. J. Bacteriol. 170:2254-2262.

  34. Kuivila, K. M., J. W. Murray, A. H. Devol, M. E. Lidstrom and C. E. Reimers. 1988. Methane cycling in the sediments of Lake Washington. Limn. and Oceanogr. 33:571-581.

  35. Lidstrom, M. E. 1988. Isolation and characterization of marine methanotrophs. Ant. v. Leeuw. J. Microbiol. 54:189-199.

  36. Ward, B. B., K. A. Kilpatrick, A. E. Wopat, E. C. Minnich and M. E. Lidstrom. 1989. Methane oxidation in Saanich Inlet during summer stratification. Cont. Shelf Res.9:65-75.

  37. Remsen, C. C., E. C. Minnich, R. S. Stephens and M. E. Lidstrom. 1989. Aerobic methane oxidation in Lake Superior sediments. J. Great Lakes Res. 15:141-146.

  38. Kim, Y. M. and M. E. Lidstrom. 1989. Plasmid analysis in pink facultative methylotrophic bacteria using a modified acetone-alkaline hydrolysis method. FEMS Microbiol. Lett. 60:125-130.

  39. Fassel, T. A., M. J. Schaller, M. E. Lidstrom and C. C. Remsen. 1990. Effect of fixation-resin combinations and ruthenium red on elucidating outer envelope structure and surface morphology of two methanotrophic bacteria. J. Electron. Microscopy Technique 14:52-62.

  40. Valentin, N., M.E. Lidstrom and F. Preusser. 1990. Microbial control by inert gases on museum collections. Studies in Conservation 35:222-230.

  41. Anderson, D.J., C.J. Morris, D.N. Nunn, C. Anthony and M.E. Lidstrom. 1990. Nucleotide sequence of the Methylobacterium extorquens sp. AM1 moxF and J genes involved in methanol oxidation. Gene 90:173-176.

  42. Meijer, W.G., L.M. Croes, B. Jenni, L.G. Lehmicke, M.E. Lidstrom and L. Dijkhuizen. 1990. Characterization of Xanthobacter strains H4-14 and 25A and enzyme profiles after growth under autotrophic and heterotrophic conditions. Arch.Microbiol. 154:225-232.

  43. DiSpirito, A.A., J.D. Lipscomb and M.E. Lidstrom. 1990. Soluble cytochromes from the marine methanotroph, Methylomonas sp. A4. J.Bacteriol. 172:5360-5367.

  44. Lidstrom, M.E. 1990. Serine transhydroxymethylases from Methylobacterium organophilum XX. Meth.Enzym. 188:365-372.

  45. Krema, C. and M.E. Lidstrom. 1990. Hydroxypyruvate reductase from Methylobacterium extorquens AM1. Meth.Enzym. 188:373-378.

  46. Chistoserdov, A.Y., Tsygankov, Y.D. and M.E. Lidstrom. 1990. Cloning and sequencing of the structural gene for the small subunit of methylamine dehydrogenase from Methylobacterium extorquens AM1: evidence for two tryptophan residues involved in the active center. Biochem.Biophys.Res.Commun. 172:211-216.

  47. DiChristina, T., R.G. Arnold, M.E. Lidstrom, and M.R. Hoffmann. 1990. Dissimilative iron reduction by the ramine eubacterium Alte3romonas putrefaciens. Water Science and Technol 20:69-79.

  48. Meijer, W.G., A.C. Arnberg, H.G. Enequist, P. Terpstra, M.E. Lidstrom and L. Dijkhuizen. 1991. Identification and organization of carbon dioxide fixation genes in Xanthobacter flavus H4-14. Molec.Gen.Genet. 225:320-330.

  49. McIntire, W.S., D.E. Wemmer, A.Y. Chistoserdov and M.E. Lidstrom. 1991. A new cofactor in a prokaryotic enzyme: Tryptophan tryptophylquinone as the redox prosthetic group in methylamine dehydrogenase. Science 252:817-824.

  50. Chistoserdov, A.Y., Y.D. Tsygankov and M.E. Lidstrom. 1991. Nucleotide sequence of the amicyanin gene from Methylobacterium extorquens AM1. DNA Sequence 2:53-55.

  51. Chistoserdov, A.Y., Y.D. Tsygankov and M.E. Lidstrom. 1991. Genetic organization of methylamine utilization genes from Methylobacterium extorquens AM1. J.Bacteriol. 173:5901-5908.

  52. Chistoserdov, A.Y. and M.E. Lidstrom. 1991. The small subunit of methylamine dehydrogenase has an unusual signal sequence. J.Bacteriol. 173:5909-5913.

  53. Chistoserdova, L. and M.E. Lidstrom. 1991. Hydroxypyruvate reductase from Methylobacterium extorquens AM1. J.Bacteriol. 173:7228-7232.

  54. Putzer, K.P., L.A. Buchholz, M.E. Lidstrom and C.C. Remsen. 1991. Separation of methanotrophic bacteria by using Percoll and its application to isolation of mixed and pure cultures. Appl.Environ.Microbiol. 57:3656-3659.

  55. Chistoserdova, L.V., and M.E. Lidstrom. 1992. Cloning, mutagenesis, and physiological effect of a hydroxypyruvate reductase gene from Methylobacterium extorquens AM1. J.Bacteriol. 174(1):71-77.

  56. Morris, C.J., and M.E. Lidstrom. 1992. Cloning of a methanol-inducible moxF promoter oand its analysis in moxB mutants of Methylobacterium extorquens AM1rif. J.Bacteriol. 174(13):4444-4449.

  57. DiSpirito, A.A., J. Gulludge, J.C. Murrell, A.K. Shiemke, M.E. Lidstrom and C.L. Krema. 1992. Trichloroethylene degradation by the membrane associated methane monooxygenase in Type I, Type II and Type X methanotrophs. Biodegradation 2:151-164.

  58. Chistoserdov, A.Y., J. Boyd, F.S. Mathews and M.E. Lidstrom. 1992. The genetic organization of the mau gene cluster of the facultative autotroph Paracoccus denitrificans. Biochem. Biophys. Res. Commun. 184:1226-1234.

  59. Grant, S.B., E.J. List and M.E. Lidstrom. 1993. Kinetic analysis of virus adsorption and inactivation in batch experiments. Water Resource Res. 29:2067-2085.

  60. Arps, P.J., E. Minnich, G. Fulton and M.E. Lidstrom. 1993. Genetics of serine pathway enzymes in Methylobacterium extorquens AM1: phosphoenolpyruvate carboxylase and malyl CoA lyase. J. Bacteriol. 175:3776-3783.

  61. Waechter-Brulla, D., A.A. DiSpirito and M.E. Lidstrom. 1993. Genetics of methanol oxidation in Methylomonas sp. A4. J. Bacteriol. 175:3767-3775.

  62. Morris, C.J., F. Biville, E. Turlin, E. Lee, K. Ellerman, W.-H. Fan, R. Ramamoorthi, A.L. Springer and M.E. Lidstrom. 1994. Isolation, phenotypic characterization and complementation analysis of mutants in Methylobacterium extorquens AM1 unable to synthesize pyrroloquinoline quinone and sequence of pqqD, pqqG and pqqC. J. Bacteriol. 176:1746-1755.

  63. Chistoserdova, L. and M.E. Lidstrom. 1994. The genetics of the serine cycle in Methylobacterium extorquens AM1: identification of sgaA and sequence of sgaA, hprA and mtdA. J. Bacteriol. 176:1957-1968.

  64. Chistoserdov, A.Y., L.V. Chistoserdova, W.S. McIntire and M.E. Lidstrom. 1994. The genetic organization of the mau gene cluster in Methylobacterium extorquens AM1: complete nucleotide sequence and generation and characteristics of mau mutants. J. Bacteriol. 176:4052-4065.

  65. Chistoserdov, A.Y., W.S. McIntire, F. S. Mathews and M.E. Lidstrom. 1994. The organization of the methylamine utilization (mau) genes in Methylophilus methylotrophus W3A1. J. Bacteriol. 176:4073-4080.

  66. Nguyen, H.T., A.K. Shiemke, S.J. Jacobs, B.J. Hales, M.E. Lidstrom and S.I. Chan. 1994. The nature of the copper ions in the membranes containing the particulate methane monooxygenase from Methylococcus capsulatus Bath. J. Biolog. Chem. 269:14995-15005.

  67. Lidstrom, M.E., C. Anthony, F. Biville, F. Gasser, P. Goodwin, R.S. Hanson and N. Harms. 1994. New unified nomenclature for genes involved in the oxidation of methanol in Gram-negative bacteria. FEMS Microbiol. Lett. 117:103-106.

  68. Chistoserdova, L., M. Kuhn and M.E. Lidstrom. 1994. Identification of a promoter region for mxaF (moxF) from the Type I methanotroph, Methylobacter albus BG8. FEMS Microbiol. Lett. 121:343-348..

  69. Speer, B.S., L. Chistoserdova and M.E. Lidstrom. 1994. Sequence of the gene for a NAD(P) dependent formaldehyde dehydrogenase (class III alcohol dehydrogenase) from a marine methanotroph Methylobacter marinus A45. FEMS Microbiol. Lett. 121:349-356.

  70. Chistoserdova, L.V. and M.E. Lidstrom. 1994. Genetics of the serine cycle in Methylobacterium extorquens AM1: cloning, sequence, mutation and physiological effect of glyA, the gene for serine hydroxymethyltransferase. J. Bacteriol. 176:6759-6763.

  71. Chistoserdova, L.V. and M.E. Lidstrom. 1994. Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence and mutation of three new genes involved in C1 assimilation, orf4, mtkA and mtkB. J. Bacteriol. 176:7898-7904.

  72. Duong, M.H., S.B. Grant, and M.E. Lidstrom. 1994. Transfer solution chemistry affects mixed-phase hybridizations. Anal. Biochem. 220:431-433.

  73. Ramamoorthi, R. and M.E. Lidstrom. 1995. Transcriptional analysis of pqqD and study of the regulation of pyrroloquinoline quinone biosynthesis in Methylobacterium extorquens AM1. J. Bacteriol. 177:206-211.

  74. Semrau, J.D., A. Chistoserdov, J. Lebron, A. Costello, J. Davagnino, E. Kenna, A.J. Holmes, R. Finch, J.C. Murrell and M.E. Lidstrom. 1995. Particulate methane monooxygenase genes in methanotrophs. J. Bacteriol. 177:3071-3079.

  75. Semrau, J.D., D. Zolandz, M.E. Lidstrom and S.I. Chan. 1995. The role for copper in the pMMO of Methylococcus capsulatus Bath: a structural vs. catalytic function. J. Inorg. Biochem. 58:235-244.

  76. Gak, E.R., A.Y. Chistoserdov, and M.E. Lidstrom. 1995. Cloning, sequencing and mutation of a gene for azurin in Methylobacillus flagellatum KT. J. Bacteriol. 177:4575-4578.

  77. Holmes, A.J., A. Costello, M.E. Lidstrom and J.C. Murrell. 1995. Evidence that particulate methane monooxygenase and ammonia monooxygenase are homologous enzymes. FEMS Microbiol. Lett. 132:202-208.

  78. Springer, A.L. H.-H. Chou, W.-H. Fan, E. Lee and M.E. Lidstrom. 1995. Isolation and characterization of methanol oxidation mutants in Methylobacterium extorquens AM1: identification of new methanol oxidation complementation groups . Microbiol. (UK) 141:2985-2993.

  79. Arps, P.J., B.S. Speer, Y.M. Kim and M.E. Lidstrom. 1995. The mxaAKL genes of Methylobacter albus BG8. Microbiol. (UK). 141:2995-3004.

  80. Morris, C.J., A.L. Springer, Y.M. Kim, K.E. Perkins and M.E. Lidstrom. 1995. The identification and nucleotide sequence of mxaA, mxaC, mxaK, mxaL and mxaD genes from Methylobacterium extorquens AM1. J. Bacteriol. 177:6825-6831.

  81. Berson, O. and M.E. Lidstrom. 1996. Study of copper accumulation by the Type I methanotroph, Methylobacter albus BG8. Environ. Sci. Technol.30:802-809.

  82. Springer, A.L., R. Ramamoorthi and M.E. Lidstrom. 1996. Characterization and nucleotide sequence of pqqE and pqqF in Methylobacterium extorquens AM1. J. Bacteriol. 178:2154-2157.

  83. Chistoserdova, L.V. and M.E. Lidstrom. 1996. Molecular characterization of a chromosomal region involved in the oxidation of acetyl CoA into glyoxylate in the Icl- methylotroph, Methylobacterium extorquensAM1. Microbiol. (UK) 142:1459-1468.

  84. Nguyen, H-H-T., K.H. Nakagawa, B. Hedman, S.J. Elliott, M.E. Lidstrom, K.O. Hodgson and S.I. Chan. 1996. X-ray absorption and EPR studies on the copper ions associated with the particulate methane monooxygenase from Methylococcus capsulatus (Bath). Cu(I) ions and their implications. J. Am. Chem. Soc. 118:12766-12776.

  85. Toyama, H., L.V. Chistoserdova, and M.E. Lidstrom. 1997. Sequence analysis of pqq genes of Methylobacterium extorquens AM1 required for biosynthesis of pyrroloquinoline quinone and purification of a biosynthetic intermediate. Microbiol. (UK) 143:595-602.

  86. Springer, A.L., C.J. Morris, and M.E. Lidstrom. 1997. Molecular analysis of mxbD and mxbM, a putative sensor-regulator pair required for oxidation of methanol in Methylobacterium extorquens AM1. Microbiology 143:1737-1744.

  87. Chistoserdova, L. and M.E. Lidstrom. 1997. Molecular and mutational analysis of a DNA region separating two methylotrophy gene clusters in Methylobacterium extorquens AM1. Microbiol. (UK) 143:1729-1736.

  88. Berson, O. and M.E. Lidstrom. 1997. Cloning and chracterization of corA, a gene encoding a copper-repressible polypeptide in the Type I methanotroph, Methylomicrobium albus BG8. FEMS Microbiol. Lett., 148:169-174.

  89. Goodwin, K.D., W.J. North, and M.E. Lidstrom. 1997. Production of bromoform and dibromomethane by Giant Kelp: factors affecting release and comparison to anthropogenic bromine sources. Limnol. Oceanogr. 42:1725-1734.

  90. Smith, K.S. and M.E. Lidstrom. 1997. Methane and TCE oxidation kinetics of an estuarine methanotroph, Methylobacter sp. strain BB5.1 Appl. Env. Microbiol. 63:4617-4620.

  91. Chistoserdova, L. and M.E. Lidstrom. 1997. Identification and mutation of a gene required for glycerate kinase activity from a facultative methylotroph, Methylobacterium extorquens AM1. J. Bacteriol. 179:4946-4948.

  92. Goodwin, K.D., R.S. Oremland and M.E. Lidstrom. 1997. Degradation of brominated methanes by marine bacteria. Env. Sci. & Technol. 31:3188-3192.

  93. Toyama, H. and M.E. Lidstrom. 1998. Construction and characterization of a mutant of Methylobacterium extorquens AM1 lacking pqqA, involving biosynthesis of pyrroloquinoline quinone. Microbiology 144:183-191.

  94. Davagnino, J., A.L. Springer and M.E. Lidstrom. 1998. Purification and characterization of RNA polymerase from Methylobacterium extorquens AM1. Microbiology 144:177-182.

  95. Springer, A.L., A. J. Auman and M.E. Lidstrom. 1998. Sequence and characterization of mxaB, a response regulator involved in regulation of methanol oxidation, and of mxaW, a methanol-regulated gene in Methylobacterium extorquens AM1. FEMS Microbiol. Lett. 160:119-1214.

  96. L. Chen, M. Doi, R.C.E. Durley, A.Y. Chistoserdov, M.E. Lidstrom, V.L. Davidson and F. S. Mathews. 1998. Refined crystal structure of methylamine dehydrogenase from Paracoccus denitrificans at 1.75 Å resolution. J. Mol. Biol. 276:131-149.

  97. Chistoserdova, L., J. Vorholt, R.K. Thauer and M.E. Lidstrom. 1998. Enzymes and coenzymes thought to be archaeal-specific that are required for aerobic methylotrophy. Science 281:99-102.

  98. Connell, T.L., A.M. Costello, M.E. Lidstrom, and R.S. Oremland. 1998. A novel bacterium for the removal of methyl bromide in fumigated agricultural soils. Appl. Environ. Microbiol., 64:2899-2905.

  99. Hurst, G.B, K. Weaver, MJ. Doktycz, M.V. Buchanan, A.M. Costello and M.E. Lidstrom. 1998. MALDI-TOF analysis of polymerase chain reaction products from methanotrophic bacteria. Anal. Chem., 70:2693-2698.

  100. Toyama, H., C. Anthony and M.E. Lidstrom. 1998. Construction of insertion and deletion mxa mutants of Methylobacterium extorquens AM1 by electroporation. FEMS Microbiol. Lett. 166:1-7.

  101. Vorholt, J., L. Chistoserdova, M.E. Lidstrom and R.K. Thauer. 1998. The NADP-dependent methylene tetrahydromethanopterin dehydrogenase in Methylobacterium extorquensAM1. J. Bacteriol. 180:5351-5356.

  102. Stolyar, S., A. M. Costello, T. L. Peeples, and M. E. Lidstrom. 1999. Role of multiple gene copies in particulate methane monooxygenase activity in the methane-oxidizing bacterium Methylococcus capsulatus Bath. Microbiol (UK) 145:1235-1244.

  103. Pomper BK, Vorholt JA, Chistoserdova L, Lidstrom ME, Thauer RK. 1999. A methenyl tetrahydromethanopterin cyclohydrolase and a methenyl tetrahydrofolate cyclohydrolase in Methylobacterium extorquens AM1. Eur J Biochem. 261:475-80.

  104. Vorholt, J., L. Chistoserdova, S.M. Stolyar, R.K. Thauer, and M.E. Lidstrom. 1999. Distribution of tetrahydromethanopterin-dependent enzymes in methylotrophic bacteria and phylogeny of methenyl tetrahydromethanopterin cyclohydrolases. J. Bacteriol., 181:5750-5757.

  105. Costello, A.M. and M.E. Lidstrom. 1999. Molecular characterization of functional and phylogenetic genes from natural populations of methanotrophs in lake sediments. Appl. Env. Microbiol.65:5066-5074.

  106. Chistoserdova, L., L. Gomelsky, J.A. Vorholt, M. Gomelsky, Y.D. Tsygankov, and M.E. Lidstrom. 2000. Analysis of two formaldehyde oxidation pathways in Methylobacillus flagellatum KT, a ribulose monophosphate cycle methylotroph. Microbiol. (UK) 146:233-238.

  107. Hagemeier C.H., L. Chistoserdova, M.E. Lidstrom, R.K. Thauer, and J.A. Vorholt. 2000. Characterization of a second methylene tetrahydromethanopterin dehydrogenase from Methylobacterium extorquens AM1. Eur J Biochem. 2000 267:3762-3769.

  108. Meima, R. and M.E. Lidstrom. 2000. Characterization of the minimal replicon of a cryptic Deinococcus radiodurans SARK plasmid and development of versatile Escherichia coli-D. radioduransshuttle vectors. Appl. Env. Microbiol. 66:3856-67.

  109. Vorholt, J.A., C.J. Marx, M.E. Lidstrom, and R.K. Thauer. 2000. Novel formaldehyde activating enzyme in Methylobacterium extorquens AM1 required for growth on methanol. J. Bacteriol.,182:6645-6650.

  110. Auman, Ann J., Sergei Stolyar, and Mary E. Lidstrom. 2000. Molecular characterization of methanotrophic isolates from freshwater lake sediment. Appl. Env. Microbiol. 66:5259-5266.

  111. Korotkova, N., and M.E. Lidstrom. 2001. A connection between poly--hydroxybutyrate biosynthesis and growth on C1 and C2 compounds in the methylotroph Methylobacterium extorquens AM1. J. Bacteriol.183:1038-1046.

  112. S.M. Stolyar, M. Franke, and M. E. Lidstrom. 2001. Expression of individual copies of Methylococcus capsulatus Bath particulate methane monooxygenase genes. J. Bacteriol. 183:1810-1812.

  113. Meima, R., H.M. Rothfuss, L. Gewin, and M.E. Lidstrom. 2001. Promoters in the radioresistant bacterium Deinococcus radiodurans. J. Bacteriol., 183:3169-3175.

  114. Marx, C. and M. E. Lidstrom. 2001. Development of improved broad host range vectors for use in methylotrophs and other Gram-negative bacteria. Microbiology 147:2065-75.

  115. Auman, A., C. Speake and M.E. Lidstrom. 2001. Nitrogen fixation in methanotrophic bacteria. Appl Env. Microbiol., 67:4009-16.

  116. Lidstrom ME, Chistoserdova L. 2002. Plants in the pink: cytokinin production by Methylobacterium. J Bacteriol. 2002 184(7):1818

  117. Van Dien, S. and M. E. Lidstrom. 2002. A stoichiometric model for evaluating the metabolic capabilities of the facultative methylotroph Methylobacterium extorquens AM1, with application to reconstruction of C3 and C4 metabolism. Biotech. Bioeng. 78(3):296-312.

  118. Korotkova N., L.Chistoserdova, V. Kuksa,and M.E. Lidstrom. 2002. Glyoxylate regeneration pathway in the methylotroph Methylobacterium extorquens AM1. J Bacteriol 184:1750-8.

  119. Costello AM, Auman AJ, Macalady JL, Scow KM, Lidstrom ME. 2002. Estimation of methanotroph abundance in a freshwater lake sediment. Environ Microbiol. 8:443-50.

  120. Auman AJ, Lidstrom ME. 2002. Analysis of sMMO-containing type I methanotrophs in Lake Washington sediment. Environ Microbiol. 9:517-24.

  121. Korotkova N, Chistoserdova L, Lidstrom ME. Poly-beta-hydroxybutyrate biosynthesis in the facultative methylotroph Methylobacterium extorquens AM1: identification and mutation of gap11, gap20, and phaR. J Bacteriol. 184(22):6174-81.

  122. Schmid AK, Lidstrom ME. 2002. Involvement of two putative alternative sigma factors in stress response of the radioresistant bacterium Deinococcus radiodurans. J Bacteriol. 184(22):6182-9.

  123. Toyama H, Fukumoto H, Saeki M, Matsushita K, Adachi O, Lidstrom ME. 2002. PqqC/D, which converts a biosynthetic intermediate to pyrroloquinoline quinone. Biochem Biophys Res Commun. 299(2):268-72.

  124. Marx CJ, Lidstrom ME. 2002. Broad-host-range cre-lox system for antibiotic marker recycling in gram-negative bacteria. Biotechniques. 5:1062-7.

  125. Fitzgerald KA, Lidstrom ME. 2003. Overexpression of a heterologous protein, haloalkane dehalogenase, in a poly-beta-hydroxybutyrate-deficient strain of the facultative methylotroph Methylobacterium extorquens AM1. Biotechnol Bioeng. 81(3):263-8.

  126. Marx, Christopher J, Brooke N. O’Brien, Jennifer Breezee, and Mary E. Lidstrom. 2003. Novel methylotrophy genes of Methylobacterium extorquens am1 identified using transposon mutagenesis including a putative dihydromethanopterin reductase. J. Bacteriol., 185(2):669-73.

  127. Kalyuzhnaya, M., and M.E. Lidstrom. 2003. QscR, a LysR-type transcriptional regulator and a CbbR-homolog is involved in regulation of the serine cycle genes in Methylobacterium extorquens AM1. J. Bacteriol., 185(4):1229-35.

  128. Laukel, Markus, Ludmila Chistoserdova, Mary E. Lidstrom, and Julia A. Vorholt. 2003. The tungsten-containing formate dehydrogenase from M. extorquens AM1. Purification and properties. Eur. J. Biochem., 270(2):325-33.

  129. Van Dien, Stephen J., Tim Strovas, and Mary E. Lidstrom. 2003. Quantification of the Central Metabolic Fluxes in the Facultative Methylotroph Methylobacterium extorquens AM1 using 13C-Label Tracing and Mass Spectrometry. Biotech. Bioeng. 84(1):45-55

  130. Zhang, Meng and Mary E. Lidstrom. 2003. Promoters and transcripts for genes involved in methanol oxidation in Methylobacterium extorquens AM1. Microbiology, 149(Pt 4):1033-40.

  131. Van Dien, Stephen J., Yoko Okubo, Melinda T. Hough, Natalia Korotkova,Tricia Taitano, and Mary E. Lidstrom. 2003. Reconstruction of C3 and C4 Metabolism in Methylobacterium extorquens AM1 using Transposon Mutagenesis. Microbiology,149:601-609.

  132. Chistoserdova, L., A. Lapidus and M.E. Lidstrom. 2003. Methylotrophy in Methylobacterium extorquens AM1 from a Genomic Point of View, J. Bacteriol., 185(10):2980-7.

  133. Van Dien, Stephen J., Christopher J. Marx, Brooke N. O’Brien, and Mary E. Lidstrom. 2003. Genetic Characterization of the Carotenoid Biosynthetic Pathway in Methylobacterium extorquens AM1, and the Isolation of a Colorless Mutant. Appl. Env. Microbiol.69:7563-6.

  134. Marx CJ, Chistoserdova L, and ME Lidstrom ME. 2003. Formaldehyde-detoxifying role of the tetrahydromethanopterin-linked pathway in Methylobacterium extorquens AM1. J Bacteriol.;185(24):7160-8.

  135. Marx CJ, Laukel M, Vorholt JA, and ME Lidstrom. 2003. Purification of the formate-tetrahydrofolate ligase from Methylobacterium extorquens AM1 and demonstration of its requirement for methylotrophic growth. J Bacteriol. 185(24):7169-75.

  136. Lidstrom, M.E. Meldrum, D.R. 2003. Life-on-a-Chip. Nature Reviews Microbiology 1, 158-164.

  137. Chistoserdova, Ludmila , Markus Laukel, Jean-Charles Portais, Julia A. Vorholt, and Mary E. Lidstrom. 2004. Multiple Formate Dehydrogenase Enzymes in the Facultative Methylotroph Methylobacterium extorquens AM1 are Dispensable for Growth on Methanol. J. Bacteriol. 186:22-28.

  138. Korotkova N, Lidstrom ME. 2004. MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation.J Biol Chem. Epub ahead of print

  139. Marx CJ, Lidstrom ME. 2004. Development of an insertional expression vector system for Methylobacterium extorquens AM1 and generation of null mutants lacking mtdA and/or fch. Microbiology. 150:9-19.

  140. Chistoserdova L, Jenkins C, Kalyuzhnaya M, Marx CJ, Lapidus A, Vorholt JA, Staley JT, Lidstrom ME. 2004. The Enigmatic Planctomycetes May Hold a Key to the Origins of Methanogenesis and Methylotrophy. Mol Biol Evol. 21:1234-41.

  141. Marx CJ, Miller JA, Chistoserdova L, Lidstrom ME. 2004. Formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400. J Bacteriol. 186(7):2173-8.

  142. Hope, Janiece L., Bryan J. Prazen, Erik J. Nilsson, Mary E. Lidstrom and Robert E. Synovec. 2004. Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection: analysis of amino acid and organic acid trimethylsilyl derivatives, with application to the analysis of metabolites in rye grass samples. Talanta 65:380-388.

  143. Kalyuzhnaya, M.G., M.E. Lidstrom, and L. Chistoserdova. 2004. Utility of environmental probes targeting ancient enzymes: methylotroph detection in Lake Washington. Microb. Ecol. 2004 48(4): 463-72.

  144. Korotkova N., M. E. Lidstrom, and L. Chistoserdova. Identification of Genes Involved in the Glyoxylate regeneration cycle in Methylobacterium extorquens AM1 including two new genes, meaC and meaD. J. Bacteriol. 2005, 187(4): 1523-1526.

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