Persistent Organic Pollutants (POPs) are widely distributed in marine and estuarine environments. Besides of their persistence POPs are toxic, and bioaccumulative, therefore able to inflict adverse effects on biotic communities. Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were measured in the reproductive season of dolphinfish, Coryphaena hippurus, captured in Mazatlan, Mexico, to characterize possible gender and tissue bioaccumulation differences. The common dolphinfish C. hippurus is an oceanic pelagic predator highly appreciated to both sport and commercial fishing in the northwest Pacific coast of Mexico. This species is sexually dimorphic, and they tend to school by sex. Bioaccumulation and distribution of OCPs and PCBs within an organism could be related to the physicochemical characteristics of the contaminants, as well as intrinsic biological factors such as gender, reproductive status and age. There was a clear relationship between overall contaminant concentration and lipid content of each tissue showing a general trend of: muscle Keywords: POPs, Gender-related bioaccumulation, Coryphaena hippurus.