Invention of printing: 1439, Gutenberg’s Bible was printed in 1455
1482 the first mathematics book printed: Campanus of Novara's edition of Euclid's Elements.
In 1484 Chucke: used for
In 1646 Vieta, used for B(D^{2} + BD).

Mathematical Symbols “+”, ““ and “=”: 1202 Fibonacci: “plus”, “minus”, 1556 Tartalia: p., m.
Sign + was first used in 1360 by N.Oresme, in 1489 J.Widman writes an arithmetic book in German which contains both signs + and  . They were also used in 1514 by V.Hoecke, and in 1542 by R.Recorde, who also used sign “=” in 1557. In 1631 William Oughtred (15751660) used symbols “×”, “/”, ””, sin, cos, and introduced logarithmic scale.

Late works of Leonardo da Vinci and Boticelli
Michelangelo Buonarroti 1475–1564 sculptor, painter, architect, poet, and engineer; “Renaissance man”
Raphael 1483–1520 painter and architect
 Cultural context: High Renaissance 14901527 (since death of Lorenzo Medici till sack of Rome by Charles V)
1492 Christopher Columbus discovers "West Indies", 14991500 Amerigo Vespucci, 1519 Ferdinand Magellan

1494 Luca Pacioli (14451509) Franciscan friar, publishes Summa de arithmetica, geometria, proportioni et proportionalita which is a review of the whole of mathematics covering arithmetic, trigonometry, algebra, tables of moneys, weights and measures, games of chance, doubleentry bookkeeping and a summary of Euclid's geometry. Another book of Pacioli De divina proportione completed in 149698 was illustrated by his friend, Leonardo da Vinci. Pacioli was accused in plagiarism, because the content was mainly taken from the works of Piero della Francesca, without giving credits.
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