The Lock and Key Theory of Enzyme Function



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The Lock and Key Theory of Enzyme Function

1
© David Faure, InThinking
www.biology-inthinking.co.uk


Aim:

To learn the structure of enzymes and how to describe the parts of an enzyme, and how enzymes function.
Questions
1. What is an enzyme
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2. Define the active site
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Note:
Enzymes are proteins which work as biological catalysts. They speedup the rate of a chemical reaction without themselves being changed. The actual structure of enzymes is complex they are often large proteins with a specific D shape. The most important part of the shape on an enzyme is the active site. The active site must fit the shape of the enzyme’s substrate. It is where the substrate molecules bind and undergo a chemical reaction. Each enzyme has a particular shape of active site. They can each only catalyse one specific reaction. This is known as “enzyme-substrate specificity

The Lock and Key Theory of Enzyme Function

2
© David Faure, InThinking
www.biology-inthinking.co.uk


3. Explain how an enzyme attaches to a substrate using the lock and key hypothesis.
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……………………………………………………………………………………………………………………………………………………………. Research how temperature, pH and the concentration of substrate can speedup an enzyme catalysed reaction.
5. What changes when an enzyme becomes denatured
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6. For each factor complete the table below.
Factor
How can this factor speedup an enzyme reaction
Concentration of substrate

pH

Temperature

7. Draw your own diagrams showing an enzyme and substrate reacting to produce anew product.


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