31 May - 04 Jun 2010
Dr. Carolien de Kovel and Dr. Bobby Koeleman,
Complex Genetics Group, Dpt. of Genetics, UMC Utrecht
Complex Genetics Group, Stratenum, UMC Utrecht, Universiteitsweg 100
Course aims and content:
Diseases such as rheumatoid arthritis, diabetes, cardiovascular diseases, and psychiatric disorders are cumulatively very frequent in the population. Although these diseases are not inherited in a Mendelian fashion, they certainly have genetic components, and cases cluster in families. While a single genetic difference is usually enough to cause a Mendelian disorder, complex diseases are caused by the accumulation or interaction of a number of genetic and environmental factors. Over the past ten years, these diseases have attracted ever more scientific attention. Firstly because they are common, with a life-long risk of developing such a disease of 60%, and they are therefore a major burden to society, and secondly, because new developments in technology have made it possible to detect the relatively weak genetic risk factors that are predicted to underlie these complex diseases. This field is continuously in development as we keep learning new facts about the genetic background of these complex disorders and techniques become cheaper to use and more encompassing.
The course will introduce the field of complex disease genetics, and discuss the methodology and technology with which these common disease genes are being identified. We will discuss the population genetic theory behind these studies and give an overview of the results so far. At the end of the course you will be able to design a valid complex genetics study.
Note: You are urged to first attend the course “ Introduction to Bioinformatics for Molecular Biologists” before taking this course
Please register online on the cgdb website: www.cgbd.nl (courses). CGDB students have priority in registration until 3 weeks before the start of the course.
The programme below is that of the previous edition of this course, just to give you an impression of its contents. It will be replaced by the 2010 programme schedule as soon as possible.
Monday, May 25
9:00-10:00 Lecture: Introduction Complex Genetics - R. Ophoff - Janis Joplin
10:00-11:00 Lecture: brush-up concepts and technology; types of DNA variation (incl. structural) - B. Koeleman - Janis Joplin
12:30 -17:00 Exercise: Obtaining and interpreting genetic data - B. Koeleman / R. Ophoff - CLZ2
Tuesday, May 26
9:00-10:00 Lecture: concepts & genetic epidemiology & statistics (1) - B. Alizadeh - Raadszaal
10:00-11:00 Lecture: genetic architecture of Complex diseases - C. de Kovel - Raadszaal
12:30-13:30 Lecture: concepts & genetic epidemiology & statistics (2) - B. Alizadeh - CLZ2
13:30-17:00 Excercise statistics and epidemiology - B. Alizadeh - CLZ2
Wednesday, May 27
9:00-10:00 Lecture: Examples of complex genetics research: schizophrenia, also CNV results - R. Ophoff - Janis Joplin
10:00-11:00 Lecture: Examples of complex genetics research: Diabetes - B. Koeleman - Janis Joplin
12:30-17:00 Excercise: working with genome-wide association data - B. Koeleman/ C. de Kovel -CLZ2
Thursday, May 28
9:00-10:00 Lecture: looking ahead, next generation sequencing;technology and possibilities - E. Cuppen - Janis Joplin
10:00-11:30 Reading: personal genomics, papers with questions - E. Cuppen - Janis Joplin
11:30-12:30 Exercise 23andme (www.23andme.com) on E. Cuppen’s data - E. Cuppen - Janis Joplin
13:00-17:00 Lecture and excercise: role of human polymorphisms in microRNA-regulated gene expression - S. Perseng - Janis Joplin*
Friday, May 29
9:00-10:00 Lecture: strategies and pitfalls in gene hunting - B. Alizadeh - Jimi Hendrix
10:00-11:00 Lecture: population structure and cryptic relatedness - C. de Kovel - Jimi Hendrix
12:30-15:30 Excercise: designing a project proposal - B. Koeleman - Jimi Hendrix
15:30-17:00 Presentations - all available - CLZ1